Just had to take a horse to my vet this past week for some bobo's on his knees. I asked about the poly and he said that, a loading dose is needed for the first month, and then once month after that. Also that is was to be given IV, not IM. I do trust Dr Smitherman's advise, since he rides and competes, as well as doctors on Cutting horses. While his wife competes on barrels, he tries to keep up with the ever changing medical field on Joint health.