Once I realized how much more comfortable my horse was with joint lubricants, I went to Sam's and bought the biggest bottle of Tripleflex they had - it has the highest amounts of MSM, Glucosamine, Chondroitin and HA that I could find. I am telling ya'll, that stuff works!! I can tell if I forget to take it a few days - not put-me-in-bed pain but just low level discomfort that makes me kinda biotchy. Never knew what the problem was, but now that it is gone, I sure do. My shoulders, knees, elbows all feel better. As I said, the pain wasn't enough to keep me in bed, just was enough to make me not want to do what I love and what need to do in a day. And I don't take as much Tylenor anymore, except for headaches.