CDC council says fewer postexposure rabies vaccine doses needed

health advisory committee recommends four postexposure rabies vaccine doses, rather than five, for people without previous rabies vaccinations.

The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention voted June 24 to recommend the reduction for naive patients. The 15-member committee provides advice and guidance to the Department of Health and Human Services and the CDC.

The CDC is recommending that state and local health departments and health care providers plan to implement the dosage recommendations after provisional guidelines are available, but delay implementing changes until after the formal updated recommendations are published in an upcoming issue of the CDC’s Morbidity and Mortality Weekly Report. The report containing those changes is expected to be published within several months of the June 24 meeting.

An online Q-and-A page from the CDC states a panel of rabies experts reviewed rabies studies and literature on rabies pathogenesis, vaccine trials, animal studies, epidemiologic surveillance, and health economics prior to the committee’s recommendation.

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